Lidocaine permeation from a lidocaine NaCMC/gel microgel formulation in microneedle-pierced skin: vertical (depth averaged) and horizontal permeation profiles
نویسندگان
چکیده
منابع مشابه
The effects of chemical and physical penetration enhancers on the percutaneous permeation of lidocaine through equine skin
BACKGROUND The effect of physical and chemical permeation enhancers on in vitro transdermal permeation of lidocaine was investigated in the horse.Therefore, the effect of six vehicles (phosphate-buffered saline (PBS), 50% ethanol, 50% propylene glycol, 50% isopropylalcohol, 50% isopropylalcohol/isopropylmyristate and 50% dimethylsulfoxide) was examined as well as the effect of microneedle pretr...
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Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxid...
متن کاملSkin preparation and permeation experiments
First, excised human skin obtained from abdominal plastic surgery is prepared for storage. In this procedure, the subcutaneous fatty tissue is separated from the outer skin layers, namely the epidermis and the dermis by a scalpel. Second, the epidermis is separated from the underlying dermis by a heat-separation technique. The separated epidermis will be used for subsequent permeation experimen...
متن کاملPermeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin
BACKGROUND The present study was designed to evaluate the extent to which pretreatment with microneedles can enhance skin permeation of nanoparticles in vitro and in vivo. Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection. METHODS AND RESULTS ...
متن کاملPolarity and permeation profiles in lipid membranes.
The isotropic (14)N-hyperfine coupling constant, a(o)(N), of nitroxide spin labels is dependent on the local environmental polarity. The dependence of a(o)(N) in fluid phospholipid bilayer membranes on the C-atom position, n, of the nitroxide in the sn-2 chain of a spin-labeled diacyl glycerophospholipid therefore determines the transmembrane polarity profile. The polarity variation in phosphol...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2015
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-015-0229-z